NCEMI eTools

Opioid Potency Comparison
Analgesic potency of opioids
Oral-parenteral ratio: for example, morphine is 6 times more potent parenterally than orally.
Potency relative to morphine: for example, hydromorphone is 6 times more potent than an equal dose of morphine when given parenterally.
Mitchell JP: General Care of the Patient, in Manual of Medical Therapeutics, 26th ed by Claiborne D and Ridner M (eds). Little, Brown and Co. 1989. p5.
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DRUGORAL-PARENTERAL POTENCY RATIOPARENTERAL POTENCY RELATIVE TO MORPHINE (for equal doses)
Morphine1:61.0
Codeine2:30.1
Hydromorphone1:56.0
Meperidine1:40.15
Methadone1:21.0
Oxycodone1:21.0

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